AKI on CKD ํ™˜์ž๋„ hydration์„ ํ•ด์ค˜์•ผ ํ• ๊นŒ ํ•œ๋‹ค๋ฉด ์‹œ๊ฐ„๋‹น ๋ช‡ cc ์†๋„๋กœ

Q (์‚ฌ์šฉ์ž ์งˆ๋ฌธ)

AKI on CKD ํ™˜์ž๋„ hydration์„ ํ•ด์ค˜์•ผ ํ• ๊นŒ? ํ•œ๋‹ค๋ฉด ์‹œ๊ฐ„๋‹น ๋ช‡ cc ์†๋„๋กœ ์ค˜

A (b ์‘๋‹ต)

๊ฒฐ๋ก : AKI on CKD๋ผ๊ณ  ํ•ด์„œ ์ž๋™์œผ๋กœ hydration ํ•˜๋Š” ๊ฑด ์•„๋‹ˆ๊ณ , volume depletion/prerenal AKI๊ฐ€ ์˜์‹ฌ๋  ๋•Œ๋งŒ ์กฐ์‹ฌ์Šค๋Ÿฝ๊ฒŒ ์ค๋‹ˆ๋‹ค. CKD, HF, edema, pulmonary congestion ์žˆ์œผ๋ฉด ์˜คํžˆ๋ ค fluid overload๋กœ AKI/ํ˜ธํก๊ณค๋ž€์ด ์•…ํ™”๋  ์ˆ˜ ์žˆ์–ด์„œ โ€œ์ผ๋‹จ ์ˆ˜์•กโ€์€ ์œ„ํ—˜ํ•ฉ๋‹ˆ๋‹ค.

๋จผ์ € volume status๋ฅผ ๋‚˜๋ˆ ์•ผ ํ•ฉ๋‹ˆ๋‹ค.

1) Hypovolemic / prerenal AKI ์˜์‹ฌ - ๊ตฌํ† /์„ค์‚ฌ/์„ญ์ทจ์ €ํ•˜ - ์ด๋‡จ์ œ ๊ณผ๋‹ค - dry mucosa, poor skin turgor - orthostatic hypotension - tachycardia - low JVP/IVC collapse - BUN/Cr ์ƒ์Šน ํŒจํ„ด, ๋†์ถ•๋‡จ ๋“ฑ
โ†’ ์ด ๊ฒฝ์šฐ isotonic crystalloid hydration ๊ณ ๋ ค. KDIGO/์ผ๋ฐ˜ AKI ์›์น™์ƒ hypovolemia ๊ต์ •์€ ์ค‘์š”ํ•˜๊ณ , ์ˆ˜์•ก์€ crystalloid ๊ธฐ๋ฐ˜. (KDIGO AKI; AAFP AKI review)

2) Euvolemic ๋˜๋Š” ๋ถˆํ™•์‹ค - edema ์—†์Œ/ํ˜ธํก ์•ˆ์ • - IVC ์• ๋งค - ์„ญ์ทจ์ €ํ•˜ ์•ฝ๊ฐ„
โ†’ ์†Œ๋Ÿ‰ trial ํ›„ ์žฌํ‰๊ฐ€. ๋ฌด์ž‘์ • maintenance ๋งŽ์ด X.

3) Hypervolemic AKI / cardiorenal ์˜์‹ฌ - pitting edema - JVP ์ƒ์Šน - pulmonary edema, crackle/B-line - dyspnea, ์‚ฐ์†Œ์š”๊ตฌ๋Ÿ‰ - HF/๊ฐ„๊ฒฝํ™”/nephrotic syndrome
โ†’ hydration๋ณด๋‹ค๋Š” fluid restriction, diuretic, ์›์ธ ์น˜๋ฃŒ ์ชฝ. ์ˆ˜์•ก ์ฃผ๋ฉด ์•…ํ™” ๊ฐ€๋Šฅ.

์†๋„๋Š” ์–ด๋–ป๊ฒŒ ์žก๋‚˜?

์ƒํƒœ๋ณ„ ์‹ค์ „ ๊ฐ๊ฐ์€:

๋ช…ํ™•ํ•œ shock/hypoperfusion:
- isotonic crystalloid bolus, ์˜ˆ: 250โ€“500 mL์”ฉ ์ฃผ๊ณ  ์ฆ‰์‹œ ์žฌํ‰๊ฐ€
- CKD/HF๋ฉด 500 mL ํ•œ ๋ฒˆ์— ๋ฐ€๊ธฐ๋ณด๋‹ค 250 mL aliquot์ด ์•ˆ์ „

ํƒˆ์ˆ˜ ์˜์‹ฌ์ด๋‚˜ hemodynamically stable:
- 0.9% NS ๋˜๋Š” balanced crystalloid 60โ€“100 mL/hr ์ •๋„๋กœ ์‹œ์ž‘
- ๋…ธ์ธ/CKD/HF/edema risk ์žˆ์œผ๋ฉด 40โ€“60 mL/hr์ฒ˜๋Ÿผ ๋‚ฎ๊ฒŒ ์‹œ์ž‘ ๊ฐ€๋Šฅ
- 2โ€“4์‹œ๊ฐ„๋งˆ๋‹ค lung sound, SpO2, JVP, edema, urine output, BP ์žฌํ‰๊ฐ€

๋‹จ์ˆœ maintenance๊ฐ€ ํ•„์š”ํ•œ CKD/์‹ฌ๋ถ€์ „ ์œ„ํ—˜๊ตฐ:
- NICE ๊ธฐ์ค€ ์ผ๋ฐ˜ maintenance๋Š” 25โ€“30 mL/kg/day์ง€๋งŒ,
- renal impairment/cardiac failure/frail์—์„œ๋Š” 20โ€“25 mL/kg/day ์ดํ•˜๋กœ ์ค„์ด๋ผ๊ณ  ๊ถŒ๊ณ 
- ๋Œ€์ถฉ 70 kg์ด๋ฉด 20โ€“25 mL/kg/day = 1400โ€“1750 mL/day โ‰ˆ 60โ€“75 mL/hr
- ํ•˜์ง€๋งŒ ์‹ค์ œ๋ก  oral intake, urine output, overload ์—ฌ๋ถ€ ๋ณด๊ณ  ๋” ์ค„์ž„

ER์—์„œ ๋‚˜๋Š” ์ด๋ ‡๊ฒŒ ์ ‘๊ทผํ•  ๋“ฏ:

  1. AKI on CKD ํ™˜์ž ์˜ค๋ฉด ๋จผ์ € ์ˆ˜์•ก ์ค„ AKI์ธ์ง€ ํ™•์ธ
    - BP, HR, fever/sepsis, vomiting/diarrhea, PO intake, diuretics/ACEi/ARB/NSAIDs - JVP, edema, lung US B-lines, IVC, CXR - urine output/foley ๊ณ ๋ ค
  2. ํƒˆ์ˆ˜ ๋ช…ํ™• + ํ˜ธํก ๊ดœ์ฐฎ์Œ โ†’ 250โ€“500 mL bolus or 60โ€“100 mL/hr๋กœ ์‹œ์ž‘ ํ›„ ์žฌํ‰๊ฐ€
  3. CKD + HF/edema/dyspnea ์žˆ์œผ๋ฉด โ†’ 40โ€“60 mL/hr ์ดํ•˜ ๋˜๋Š” holdํ•˜๊ณ  bedside US/CXR ๋ณด๊ณ  ๊ฒฐ์ •
  4. pulmonary congestion ์žˆ์œผ๋ฉด โ†’ hydration X, overload/cardiorenal ๊ด€๋ฆฌ
  5. K, bicarbonate, uremic symptom, refractory overload ์žˆ์œผ๋ฉด nephro/dialysis indication ํ‰๊ฐ€

ํ•œ ์ค„ ๋‹ต:
AKI on CKD๋„ prerenal์ด๋ฉด hydration, ํ•˜์ง€๋งŒ ์†๋„๋Š” CKD/HF ์œ„ํ—˜ ๋•Œ๋ฌธ์— ๋ณดํ†ต 40โ€“100 mL/hr ๋ฒ”์œ„์—์„œ ์กฐ์‹ฌ์Šค๋Ÿฝ๊ฒŒ, ๋ถˆ์•ˆํ•˜๋ฉด 250 mL์”ฉ challenge ํ›„ ์žฌํ‰๊ฐ€๊ฐ€ ์•ˆ์ „ํ•ฉ๋‹ˆ๋‹ค. edema/ํ์šธํ˜ˆ ์žˆ์œผ๋ฉด ์ˆ˜์•ก๋ณด๋‹ค diuresis/์›์ธ์น˜๋ฃŒ ์ชฝ์ž…๋‹ˆ๋‹ค. (KDIGO AKI; NICE IV fluids CG174)

(quick: gpt-5.5)