ํ‹ฐ์•„๋ฏผ / Thiamine

์ •์˜

Thiamine์€ Wernicke encephalopathy์˜ ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ์— ์‚ฌ์šฉํ•˜๋Š” ๋น„ํƒ€๋ฏผ B1์ด๋‹ค.

์ž„์ƒ ํ•ต์‹ฌ

์‘๊ธ‰์ƒํ™ฉ์—์„œ risk ๋Œ€๋น„ benefit์ด ์ปค์„œ, Wernicke ๊ฐ€๋Šฅ์„ฑ์ด ์žˆ์œผ๋ฉด ์ง€์ฒดํ•˜์ง€ ์•Š๊ณ  ํˆฌ์—ฌํ•œ๋‹ค. DT์ฒ˜๋Ÿผ ๋ณด์ด๋Š” alcohol-related delirium์—์„œ๋„ Wernicke๊ฐ€ ์„ž์—ฌ ์žˆ์„ ์ˆ˜ ์žˆ์–ด ํˆฌ์—ฌ threshold๋ฅผ ๋‚ฎ๊ฒŒ ์žก๋Š”๋‹ค. Thiamine ํˆฌ์—ฌ๋Š” DT ์น˜๋ฃŒ๋ฅผ ๋Œ€์ฒดํ•˜์ง€ ์•Š๋Š”๋‹ค.

์ง„๋‹จ

Chronic alcohol user, malnutrition, vomiting, poor intake, confusion์ด ์žˆ์œผ๋ฉด thiamine ํ•„์š”์„ฑ์„ ๊ณ ๋ คํ•œ๋‹ค. Ocular sign์ด๋‚˜ ataxia๊ฐ€ ์žˆ์œผ๋ฉด Wernicke ์ชฝ ๊ฐ€๋Šฅ์„ฑ์ด ๋” ๋†’์•„์ง„๋‹ค.

์น˜๋ฃŒ

Wernicke ๊ฐ€๋Šฅ์„ฑ์ด ์žˆ์œผ๋ฉด parenteral thiamine์„ ์‚ฌ์šฉํ•œ๋‹ค. Hypoglycemia๊ฐ€ ์žˆ์œผ๋ฉด dextrose๋ฅผ ์ง€์—ฐํ•˜์ง€ ์•Š๋˜ thiamine๋„ ์ฆ‰์‹œ ๊ฐ™์ด ๋˜๋Š” ์„ ํ–‰ ํˆฌ์—ฌ๋ฅผ ๊ณ ๋ คํ•œ๋‹ค. Mg, K, phosphate ๋“ฑ ์ „ํ•ด์งˆ ์ด์ƒ๋„ ํ•จ๊ป˜ ํ™•์ธํ•˜๊ณ  ๊ต์ •ํ•œ๋‹ค.

์ถœ์ฒ˜

NCBI Bookshelf Wernicke Encephalopathy 2026; EFNS Wernicke guideline.

๐ŸŒฑ ์ถœ์ฒ˜ raw


๋ณธ ๋ฌธ์„œ๋Š” ํ•™์Šตยท์ฐธ๊ณ ์šฉ์ด๋ฉฐ ์‹ค์ œ ์ง„๋ฃŒ ๊ฒฐ์ •์€ ์ž„์ƒ์˜์˜ ํŒ๋‹จ์ž…๋‹ˆ๋‹ค.

๐Ÿ“ ์ถ”๊ฐ€ (2026-05-12, source: 2026-05-12-1129-2dcba6a3.md)

์ •์˜

Wernicke encephalopathy์˜ ์˜ˆ๋ฐฉ ๋ฐ ์น˜๋ฃŒ์— ์‚ฌ์šฉํ•˜๋Š” ๋น„ํƒ€๋ฏผ B1 ์ œ์ œ์ด๋‹ค.

์ž„์ƒ ํ•ต์‹ฌ

์‘๊ธ‰์ƒํ™ฉ์—์„œ risk ๋Œ€๋น„ benefit์ด ์ปค์„œ ์˜์‹ฌ๋˜๋ฉด ์ผ๋‹จ ํˆฌ์—ฌํ•˜๋Š” ์ชฝ์ด ์•ˆ์ „ํ•˜๋‹ค. ๋งŒ์„ฑ ์Œ์ฃผ, ์˜์–‘๋ถˆ๋Ÿ‰, ๊ตฌํ† , ์„ญ์ทจ๋ถˆ๋Ÿ‰, ํ˜ผ๋ˆ ํ™˜์ž์—์„œ๋Š” ํˆฌ์—ฌ threshold๋ฅผ ๋‚ฎ์ถ˜๋‹ค.

์ง„๋‹จ

Thiamine ํ•„์š” ์—ฌ๋ถ€๋Š” Wernicke triad ์™„์„ฑ ์—ฌ๋ถ€๋งŒ์œผ๋กœ ํŒ๋‹จํ•˜์ง€ ์•Š๋Š”๋‹ค. DT์ฒ˜๋Ÿผ ๋ณด์ด๋Š” alcohol-related delirium์—์„œ๋„ Wernicke๊ฐ€ ์„ž์—ฌ ์žˆ์„ ์ˆ˜ ์žˆ๋‹ค.

์น˜๋ฃŒ

Wernicke ๊ฐ€๋Šฅ์„ฑ์ด ์žˆ์œผ๋ฉด parenteral thiamine์„ ์‚ฌ์šฉํ•œ๋‹ค. ์ €ํ˜ˆ๋‹น์ด๋ฉด dextrose๋ฅผ ์ง€์—ฐํ•˜์ง€ ์•Š๋˜ thiamine๋„ ์ฆ‰์‹œ ๊ฐ™์ด ๋˜๋Š” ์„ ํ–‰ ํˆฌ์—ฌ๋ฅผ ๊ณ ๋ คํ•œ๋‹ค. Thiamine ํˆฌ์—ฌ๋Š” DT ์น˜๋ฃŒ๋ฅผ ๋Œ€์ฒดํ•˜์ง€ ์•Š์œผ๋ฉฐ benzodiazepine ๊ธฐ๋ฐ˜ withdrawal ์น˜๋ฃŒ์™€ ๋ณ‘ํ–‰ํ•œ๋‹ค.

์ถœ์ฒ˜

NCBI Bookshelf Wernicke Encephalopathy 2026; EFNS Wernicke guideline.