๋ฐœ์ž‘ ํ›„ ๋ ˆ๋น„๋ผ์„ธํƒ ๋กœ๋”ฉ vs ๊ฐ„์งˆ์ง€์†์ƒํƒœ ๋กœ๋”ฉ / Levetiracetam loading dose in seizure vs status epilepticus

์ •์˜

๋ ˆ๋น„๋ผ์„ธํƒ loading dose๋Š” ์ž„์ƒ ์ƒํ™ฉ์ด ๋‹จ์ˆœ seizure/cluster ํ›„ AED loading์ธ์ง€, benzodiazepine-refractory established convulsive status epilepticus์ธ์ง€์— ๋”ฐ๋ผ ๋‹ฌ๋ผ์ง„๋‹ค.

์ž„์ƒ ํ•ต์‹ฌ

๋‹จ์ˆœ seizure/cluster๊ฐ€ ๋ฉŽ์—ˆ๊ณ  postictal ์ƒํƒœ๋ผ๋ฉด levetiracetam 20 mg/kg IV๊ฐ€ ํ”ํžˆ ์“ฐ์ธ๋‹ค. ๋ฐ˜๋ฉด ongoing convulsion ๋˜๋Š” BZD ํ›„์—๋„ ์ง€์†๋˜๋Š” established SE๋ผ๋ฉด 60 mg/kg IV, max 4.5 g๊ฐ€ ESETT ๊ธฐ๋ฐ˜ ์šฉ๋Ÿ‰์ด๋‹ค. ์ฆ‰ โ€œseizure ๋•Œ q-PAM 20 mg/kgโ€์€ AED loading ๋งฅ๋ฝ์—์„œ๋Š” ๋งž์ง€๋งŒ, ์ง„์งœ SE 2nd-line protocol ์šฉ๋Ÿ‰์€ ์•„๋‹ˆ๋‹ค.

์ง„๋‹จ

๋น„๊ต์˜ ํ•ต์‹ฌ ์ถ•์€ ๋ฐœ์ž‘์ด ๋ฉŽ์—ˆ๋Š”์ง€์™€ BZD-refractory established SE์ธ์ง€์ด๋‹ค. ๋ฉŽ์€ ๋ฐœ์ž‘ ํ›„ ๋ณด๊ฐ• loading์ด๋ฉด ๋‚ฎ์€ ์šฉ๋Ÿ‰, ์ง€์† ๊ฒฝ๋ จ์„ฑ SE์ด๋ฉด ๋†’์€ ์šฉ๋Ÿ‰์„ ์ ์šฉํ•œ๋‹ค.

์น˜๋ฃŒ

50 kg: 20 mg/kg = 1 g, 60 mg/kg = 3 g. 70 kg: 20 mg/kg = 1.4 g, 60 mg/kg = 4.2 g. 80 kg ์ด์ƒ: 60 mg/kg๋Š” ์ตœ๋Œ€ 4.5 g ์ œํ•œ์— ๊ฑธ๋ฆด ์ˆ˜ ์žˆ๋‹ค.

์ถœ์ฒ˜

AES convulsive SE guideline 2016; ESETT NEJM 2019.

๐ŸŒฑ ์ถœ์ฒ˜ raw


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